According to a new research, women with silicone breast implants may have a higher risk of developing a rare form of lymphoma. Conducted by Dutch authors at the Netherlands Cancer Institute in Amsterdam, this study is published in the Nov. 5, 2008, issue of Journal of the American Medical Association .

Highlights of the research
a. Researchers searched a Dutch pathology database in the Netherlands for all cases of lymphoma in the breast diagnosed between 1990 and 2006.
b. They identified 11 patients around the age of 40 with anaplastic large T-cell lymphoma (ALCL).
c. Each patient was matched by age and year of diagnosis to one or more women of the control group who had other types of lymphomas in the breast.
d. Five of the ALCL patients had had breast implants for cosmetic reasons one to 23 years before their diagnosis.
e. It was seen that when compared with women who had other types of lymphoma in the breast, women with silicone breast implants had an 18-fold greater risk for developing ALCL.
f. The most common lymphoma in the control group was diffuse large B-cell lymphoma, followed by mucosa-associated lymphoid tissue-type lymphoma.
g. 1 of the 35 control patients had a breast implant prior to their lymphoma diagnosis.
h. The odds ratio for ALCL in the breast associated with silicone breast prosthesis placed for cosmetic reasons was 18.2.
i. Researchers concluded that an immune system response related to placement of the implants or toxic damage from the implants might explain the association.
j. The absolute risk of developing this cancer is about 0.1 to 0.3 per 100,000 women with implants each year.
k. The findings of this study might help scientists understand the biology of this particular malignancy.